Rena was born in Volos. She graduated from Athens University with a degree from the Historical and Archaeological department of Philosophy School. She started studying singing in her school years alongside established vocalists such as Vaso Zagori, Claudia Delmer, Fofi Rousou, Elli Paspala and Natasha Flouri. She made her stage debut alongside Foivos Delivorias, has cooperated with Panagiotis Kalantzopoulos in concerts and recordings, and is a recording vocalist in Disney and Mattel movies. She has been a member of Imam Baildi since 2011.